Content Warning: This guide includes scenes and suggestions of sexual violence and abuse.

Here focuses on the same corner of a room over billions of years, showing the same space before the room is built and even after it collapses. The graphic novel begins with scenes of the empty room in 1957, 1942, and 2007. A woman in a pink dress walks into the room in 1957. She is looking for something but cannot remember what it is. As she searches, a small panel dated 1999 shows a cat walking across the room.

In 1989, a group of four people—two elderly men, an elderly woman, and a younger woman—sit around the coffee table joking. One of the elderly men prompts the younger woman to tell her joke about the doctor. She tells them about a man who calls the doctor for test results. The doctor tells the man that he has both good and bad news to share. The good news is that the man has 24 hours to live, and the bad news is that the doctor meant to tell him the previous day. Everyone laughs, but one of the elderly men coughs and falls over. This conversation occurs in panels situated on pages that display scenes from before the house is built, spanning from 8,000 BCE to 1783 CE.